Hello John
No, that configuration will not work. That configuration would work in a dual channel memory layout, but this server has a tri-channel layout. Memory must be identical throughout the bank, and identical across the lanes. The banks are:
Bank 1: 1,2,3
Bank 2: 4,5,6
And of course the lanes are the A and B sides, coinciding with the 2 processors.
The configuration you are suggesting is dependent on a paired bank like this:
Bank 1: 1,2
Bank 2: 3,4
Bank 3: 5,6
That is not how it is laid out though. The best way to accomplish mixing the 8GB DIMMs with the 2GBs would be to populate the 8GB in 1,2,3 and the 2GB in 4,5,6 on each side. This will require 6 of each size DIMM. If you only populate 4x 8GB DIMMs then you would need to populate the 8GB DIMMs in 1,2 and the 2GB DIMMs in 4,5,6.
Either method you choose will run in Optimizer(Independent Channel) Mode. I hope that clears it up.
Thanks